Job Description

Summary

Location: Onsite. Cambridge, MA.

#LI-Onsite

About the role:

The Oncology Translational Research (OTR) group in Biomedical Research is seeking a highly motivated individual to serve as a scientist investigating mechanisms of efficacy and resistance to cutting-edge cancer therapies in prostate cancer. Working collaboratively with groups across the drug development spectrum (target identification, drug discovery, data science, and early clinical development groups), you will design and execute translational studies. You will dissect mechanisms of therapeutic efficacy and uncover both intrinsic and acquired resistance pathways and translate these insights into next‑generation strategies that enhance efficacy, durability, and/or safety of clinically validated targets. As part of a larger team, your work will serve as the basis for patient stratification and development of new therapeutic strategies to improve patient response and overall outcome.

The Oncology Translational Research (OTR) group in Biomedical Research is seeking a highly motivated individual to serve as a scientist investigating mechanisms of efficacy and resistance to cutting-edge cancer therapies in prostate cancer. You will dissect mechanisms of therapeutic efficacy and uncover both intrinsic and acquired resistance pathways and translate these insights into next‑generation strategies that enhance efficacy, durability, and/or safety of clinically validated targets. Working collaboratively with groups across the drug development spectrum (target identification, drug discovery, data science, and early clinical development groups), you will design and execute translational studies with the goal to develop new therapeutic strategies to improve patient response and overall outcome.

About the Role

Key responsibilities:

• Lead mechanism‑of‑action studies using advanced cell biology and molecular biology approaches to interrogate therapeutic response and resistance.
• Design, develop, and execute in vitro assays to elucidate key aspects of prostate cancer biology, including resistance mechanisms to emerging therapies
• Design and engineer human cell line models to enable functional screening and deep mechanistic interrogation of resistance pathways.
• Collaborate with cross-functional teams, design, execute, analyze, document experiments, and communicate results in team settings.
• Stay current with scientific literature and advancements

Essential Requirements:

• This is a dual posting. The final level and title of the offer role will be determined by the hiring team based on the skills, experience, and capabilities required to perform the role at the level the role has been offered.
• B.S./M.S. in biological/biomedical sciences
• Strong expertise in cell biology and multiple advanced molecular biology assays, preferably but not limited to studying clonal dynamics using barcoding technologies
• Robust experience studying resistance to small molecule therapies using molecular biology techniques
• Deep understanding of hormone driven cancer cell biology (e.g. prostate and breast cancer)
• Positive attitude, agility mindset, scientific curiosity, dedication, and excellent problem-solving skills
• Enthusiasm for scientific collaboration and working as part of a multi-disciplinary team.

Desirable Requirements:

• Proficiency with data mining and computational skills
• Experience completing single cell RNAseq and/or spatial transcriptomics

Novartis Compensation and Benefit Summary: 

The salary for this position is expected to range between $93,000 and $174,000 per year.

The final salary offered is determined based on factors like, but not limited to, relevant skills and

experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published

salary range based on company and market factors.

Your compensation will include a performance-based cash incentive and, depending on the level of the

role, eligibility to be considered for annual equity awards.

US-based eligible employees will receive a comprehensive benefits package that includes health, life and

disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In

addition, employees are eligible for a generous time off package including vacation, personal days,

holidays and other leaves.

Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together?

Benefits and Rewards: Learn about all the ways we’ll help you thrive personally and professionally.
Read our handbook (PDF 30 MB)

EEO Statement:

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.

Accessibility & Reasonable Accommodations

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to [email protected] or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

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